What is AlphaFold?

AlphaFold2 multimer achieved only 11% accuracy on antibody-antigen binding prediction cases.

“Alpha 2 got like I think 11% the multimemer version of this got like 11% of antibbody antigen prediction cases correct.”

AlphaFold confidence intervals on hypothesis-test statistics were found to be extremely narrow yet far from the gold-standard value, particularly for edge cases underrepresented in training data.

“What we found is that the confidence interval on that statistic of that 2x two table was extremely narrow and way far from the truth the true value of the gold standard value.”

AlphaFold: Demis Hassabis predicts it will be embedded in the discovery process of nearly every drug developed from this point forward.

“Almost every drug discovered from now on will have used AlphaFold at some point in its in the drug discovery process.”

AlphaFold-produced protein structures lack the pocket resolution needed for traditional docking, and studies including one published in Cell found no value in using them for drug discovery.

“There was this a few papers that came out. One was in cell I think last year which showed that for all the claims about alpha fold solving drug discovery people try to take alpha fold produced protein use them for traditional docking and found no value in it. Those pockets just weren't high resolution enough.”

A man used ChatGPT and AlphaFold together to sequence tumor DNA and target protein structure, successfully treating his dog's cancer, demonstrating a novel consumer-level AI bio-research workflow.

“Man uses AI to cure his dog's cancer.”