The glymphatic system clears Alzheimer-linked proteins beta-amyloid and tau specifically during deep sleep, giving a causal mechanism connecting sleep loss to dementia risk.

Curative's Anthropic API spend grew 6x per month for six to seven consecutive months, scaling from tens of thousands to millions of dollars per month.

The Stowers Institute discovered a mechanism for bone regeneration using research on African killifish and subsequently sold the discovery to Amgen.

Andromeda Surgical built and launched a surgical robot in 3 years on roughly $15 million total spend, claimed as the fastest zero-to-launch timeline in surgical robotics.

Nick Damiano on Andromeda Surgical's speed and capital efficiency from zero to launch.

The compute cost of migrating the 300 marketing campaigns was $14.28.

Curative canceled their $600,000/year Salesforce contract after replacing it with an internally vibe-coded CRM that integrates AI agents.

AI improvements in video models come primarily from language model gains and data/pipeline bug fixes, not from novel video architecture advances.

Big tech companies are on track to spend $720 billion on AI infrastructure in 2026, with AI compute workloads growing 10x per year.

Experimental memory-consolidation tools now allow researchers to selectively determine which waking memories are retained or lost during sleep, with potential therapeutic and cognitive-enhancement applications.

“It's not the stress that burns us down, it's the response to stress.”

“The transformers can't plan but they can do a very good job of pretending essentially that is in a sense.”

“Something like 46% of the emperors of Constantinople are overthrown through violence. 46%. And that's almost half.”

“If we just talk specifically about 300 million ARR, most of that's like almost 70% are agencies.”

“Every good AI is good in the same way. Every rogue AI is rogue in its own way.”

“From Bitcoin's code perspective, it didn't bend the knee. The institutions bent the knee to bring Bitcoin into it.”